Download Acetaminophen - A Medical Dictionary, Bibliography, and by Icon Health Publications PDF

By Icon Health Publications

This can be a 3-in-1 reference publication. It provides an entire scientific dictionary protecting hundreds of thousands of phrases and expressions with regards to acetaminophen. It additionally offers large lists of bibliographic citations. eventually, it offers details to clients on tips to replace their wisdom utilizing numerous net assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with learn devoted to acetaminophen. in the event that your time is effective, this publication is for you. First, you won't waste time looking the net whereas lacking loads of correct details. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing countless numbers of websites.

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Extra info for Acetaminophen - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

Aim 2 will use the human SCHAD-1 gene and in vitro transfection and transgenic mice to locate critical regulatory sequences. Based upon the SCHAD-1 crystal structure and protein homologies, Aim 3 will determine structure-function relationships of SCHAD-1 of normal and mutant SCHADs after expression in bacteria to explore the hypothesis that SCHAD-1 and long chain 3-hydroxy- acyl-CoA dehydrogenase share common structural domains. Using the human gene sequences we have determined, Aim 4 will delineate SCHAD-1 or -2 mutations in children to examine the proposal that SCHAD deficiency and environmental stresses cause a Reye's syndrome-like phenotype of acute hepatic failure.

Evaluate the efficacy of continuous infusion NAC in the late phase of toxicity. (Oral NAC has a very low bioavailability). ) Examine the time course of nitrotyrosine adducts and inflammatory cytokines in the APAP overdose patient. The development of this applicant into an independent researcher will be accomplished through this 32 Acetaminophen proposal performed under the guidance of well-established mentors, in a university research environment, with training in various analytical methods to assess drug toxicity in animal models.

Thus, based on this and other preliminary data, we propose a paradigm of acetaminophen hepatotoxicity whereby peroxynitrite generation, coupled with acetaminophen-protein adduct formation, act synergistically to cause cell lysis and death. We hypothesize that peroxynitrite generated during or as a result of acetaminophen metabolic activation is a Studies 37 major determinant of acetaminophen hepatotoxicity. To test this hypothesis, we plan to SA1) Determine the time and dose relationships between acetaminophen metabolism, NO formation, and development of toxicity; SA2) Investigate the roles of NO, superoxide, and peroxynitrite generation in acetaminophen hepatotoxicity by inhibiting NO formation and by using NO, superoxide, and peroxynitrite scavengers; and SA3) Identify the liver cells responsible for NO and superoxide generation during acetaminophen hepatotoxicity.

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