Download Advances in Nuclear Architecture by Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. PDF

By Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)

This booklet offers a photo of the state-of-the artwork within the examine of mammalian mobile nuclear structure, and lines a various variety of chapters written by means of best researchers. A key element is an emphasis on exact and repeatable quantitative research and simulation as well as the extra common organic point of view. The fusion of such fabric frames the way forward for the self-discipline. Quantitative contributions tension reproducible and powerful 3D research, utilizing a number of instruments starting from element development research to form registration equipment. organic insights contain the position of nuclear subdomains in melanoma, nuclear molecular vehicles, and a holistic view of gene transcription.

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NPM also functions in genome maintenance, as it is involved in the regulation of centrosome duplication (Gjerset 2006). 4 Nucleolin Nucleolin is also associated with cancer development, as it is highly expressed in rapidly proliferating cells, and can also be found on the cell surface in a wide variety of cancer cells (Storck et al. 2007). However, like nucleostemin and NPM, it has both tumour suppressive and oncogenic functions. Nucleolin functions in both RNA polymerase I and II transcription, as well as rRNA processing, and mRNA stabilization (Storck et al.

1994). Furthermore, gems, cleavage bodies, and PML NBs can colocalize with or lie adjacent to Cajal bodies (Dundr and Misteli 2001; Spector 2001). Various RNA and protein components of each of these bodies are also known to shuttle between structures. For example, snoRNAs are first transported to Cajal bodies for modification before they reach the nucleolus, and the Cajal body marker protein coilin can also be present in the nucleolus (Morris 2008), and the nucleolar protein fibrillarin can also shuttle to Cajal bodies (Dundr et al.

Other nucleolar proteins have functions that include the processing and maturation of non-nucleolar RNA and ribonucleoproteins, messenger RNA (mRNA) export, and the regulation of the cell cycle, DNA replication, DNA repair, cell senescence, tumour suppression, and the cell stress response (Maggi and Weber 2005; Raska et al. 2006; Boisvert et al. 2007; Dellaire and Bazett-Jones 2007; Montanaro et al. 2008; Sirri et al. 2008). 1 The Nucleolus, p53, ARF, and the Cell Stress Response Over the last 10 years, the nucleolus has emerged as a critical regulator of the p53 tumour suppressor.

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